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Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity

Authors

  • Chao-Zhan Lin

    Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China

  • Ai-Zhi Wu

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Ying Zhong

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Yu-Mei Wang

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Guang-Tian Peng

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Xian-Jun Su

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Bing-Xin Liu

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Yun Deng

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

  • Chen-Chen Zhu

    Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510405, China

  • Cui-Xian Zhang

    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. 510006, China

DOI:

https://doi.org/10.6000/1929-2279.2015.04.02.3

Keywords:

Psychotria serpens L., anti-cancer, flavonoids.

Abstract

In clinical, Psychotria serpens L. was often substitute for Caulis trachelospermi to treat cancer in China. Meanwhile, EtOAc and n-BuOH fractions of MeOH extract of P. serpens L. show power activity against H460, HepG2, Hela, and PC9/GR cell lines, and no toxic effects against normal 16HBE cell lines. In order to search significant anti-cancer active leading compounds, sevenetin (5), rutin (6), kaempferol-3- flavonoids, quercetin (1), tamarixetin-3-O-rutinoside (2), quercetin 3-O-(2G-β-D-xylopyranosy-lrutinoside) (3), kaempferol (4), tamarixO- rutino- side (7) were isolated from P. serpens L., and their structures were identified through spectroscopic techniques including NMR (1D and 2D) and MS. 2-5 were the first isolated from genus Psychotria. All of compounds were the first isolated from P. serpens.

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Published

2015-04-29

Issue

Vol. 4 No. 2 (2015): Special Issue - Natural Products for Cancer Prevention and Treatment

Section

Articles

How to Cite

Flavonoids from Psychotria serpens L., a Herbal Medicine with Anti-Cancer Activity. (2015). Journal of Cancer Research Updates, 4(2),  60-64. https://doi.org/10.6000/1929-2279.2015.04.02.3

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