Surface Functionalization of Gold Nanoparticles for Simultaneous Suppression of Cancer Stem Cells and Cancer Cells
DOI:
https://doi.org/10.6000/1929-2279.2014.03.03.1Keywords:
Gold nanoparticles, cancer cells, cancer stem cells, DNA, chromosome, histones, DNA helicase, DNA polymerase, RNA polymerase.Abstract
Surface functionalization of gold nanoparticles is designed for simultaneous suppression of cancer stem cells and cancer cells. The fundamental mechanism of the simultaneous suppression is based on the blocking against DNA polymerase, DNA helicase and RNA polymerase by positively charged gold nanoparticles introduced into nucleuses. In addition, applications of physical fields (ultrasound, X-ray or electromagnetic wave) will enhance the suppression effects of the cancer cells by interactions between gold nanoparticles and physical fields. It is predicted theoretically that the surface functionalization of gold nanoparticle is promising for radical treatments of cancers.
References
Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence. Cancer Cell 2013; 23: 347-61. http://dx.doi.org/10.1016/j.ccr.2013.01.026
Shenoy D, Fu W, Li J, et al. Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol)spacer for intracellular tracking and delivery. Int J Nanomedicine 2006; 1: 51-7. http://dx.doi.org/10.2147/nano.2006.1.1.51
Bruce A, et al. Molecular biology of the cell, 4th ed. Gerland Science. New York, USA 2002; p. 621.
Maeda H. Tumor-selective delivery of macromolecular drugs via EPR effect: Background and future prospects. Bioconjug Chem 2010; 21: 797-802. http://dx.doi.org/10.1021/bc100070g
Bruce A, et al. Molecular biology of the cell, 4th ed. Gerland Science. New York, USA 2002; p. 672.
Bruce A, et al. Molecular biology of the cell, 4th ed. Gerland Science, New York, USA 2002; p. 199.
Naruse Y. Theoretical analysis on the possible interruption of cell division by applying physical excitation to gold nanoparticles introduced in chromosomes. J Memb Sepa Technol 2013; 2: 120-24.
Williams R. Becquerel photovoltaic effect in binary compounds. J Chem Phys 1960; 32: 1505-14. http://dx.doi.org/10.1063/1.1730950
Naruse Y. Mechanical vibration model for chromosomes in metaphase of mitosis and possible application to the interruption of cell division. Biosystems 2002; 66: 55-63. http://dx.doi.org/10.1016/S0303-2647(02)00033-3
Downloads
Published
Issue
Section
How to Cite
Similar Articles
- Gregory Russell-Jones, Kirsten McTavish, John McEwan, Bruce Thurmond, Increasing the Tumoricidal Activity of Daunomycin-pHPMA Conjugates Using Vitamin B12 as a Targeting Agent , Journal of Cancer Research Updates: Vol. 1 No. 2 (2012)
- Kazeem A. Akinwumi, Vitamin E Alleviates Diethylhexyl Phthalate-Induced Haemato-logical Changes and Splenic Oxidative Injury in Male Sprague-Dawley Rats , Journal of Cancer Research Updates: Vol. 8 No. 1 (2019)
- Yao Li, Meng-Ning Wei, Wen-Ji Zhang, Zhi Shi, A HPLC-UV Method for the Quantification of Regorafenib in Tumor , Journal of Cancer Research Updates: Vol. 9 No. 1 (2020)
- S.K. Gantsev , S.R. Kzyrgalin, K.S. Gantsev, Peritumoral Lymphangiogenesis in Breast Carcinoma , Journal of Cancer Research Updates: Vol. 9 No. 1 (2020)
- Douglas O. Faigel, Vijay P. Singh, Krutika Patel, Alaa El Chami, Catherine C. Raymond, Tracy L. Landreth, Ronald J. Marler, Douglas F. Lake, Toufic Kachaamy, Safety of Endoscopic-Ultrasound-Guided Portal Injection Chemotherapy using Drug-Eluting Microbeads in a Porcine Model , Journal of Cancer Research Updates: Vol. 7 No. 4 (2018)
- Fazilet Erozgen, Hüseyin Kadioglu, Mehmet Celal Kizilkaya, Muzaffer Akinci, Ahmet Kocakusak, Adnan Hut, Mehmet Gülen, Ömer Güngörür, Rafet Kaplan, Gastrointestinal Stromal Tumors Presenting as Surgical Emergencies: A Six-Patient Case Series , Journal of Cancer Research Updates: Vol. 2 No. 4 (2013)
- N. Kearney, S. Fernando, L. Allen, K. Rogers, Inferior Vena Cava Tumour Thrombus from Nonseminomatous Germ Cell Tumour Detected with F-18 FDG PET/CT , Journal of Cancer Research Updates: Vol. 2 No. 1 (2013)
- Aparna Govindan, Jacob Paul Alapatt, Progesterone and Estrogen Receptors in Meningiomas – A Clinicopathological Analysis , Journal of Cancer Research Updates: Vol. 12 (2023)
- Jian-Hong Zhong, Le-Qun Li, Conventional Oral Systemic Chemotherapy for Postoperative Hepatocellular Carcinoma , Journal of Cancer Research Updates: Vol. 3 No. 1 (2014)
You may also start an advanced similarity search for this article.